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Will the effects plateau after a certain amount of time
NNMT is a cytosolic enzyme that methylates nicotinamide (vitamin B3) using S-adenosylmethionine (SAM) as a methyl donor
But like many effective treatments, these weight loss solutions also come with gastrointestinal (GI) side effectsconstipation being one of the most common
This makes it particularly relevant during caloric restriction, when the body is more prone to catabolizing muscle tissue for energy
GLP-1RA as an independent class of drug is also noteworthy in reduction of weight in patients with and without poor glycaemic control with multiple trials backing the efficacy of agents including semaglutide and liraglutide (116)
Whilst these effects are therapeutically beneficial for glycaemic control and weight reduction, they can potentially lead to reduced overall nutrient intake in some individuals
